(Feb 2022) When it comes to nutrition, I’m a tinkerer. I get the chance to play with stuff that mere mortals know nothing about. Lately, I’ve been experimenting with CyanthOx™, an extract from the sea buckthorn seed. Sea buckthorn is an ancient plant, found in the Tibetan Plateau, that’s considered a superfruit, full of bioactive nutrients. Puredia’s patented sea buckthorn extract is 100% plant-based, with no additives or organic solvents used. It’s a water-soluble and stable mixture of beneficial antioxidants. 

Their patented technology produces just 1 kg of extract from 300 kg of organic sea buckthorn. The extract is a rich combination of plant compounds–polyphenols, proanthocyanidins (PAC), and bioflavonoids; CyanthOx contains unique PACs called prodelphindin, but also quercetin, kaempferol and isorhamnetin. These are all water-soluble, bioactive antioxidants with multiple beneficial properties.

The potency is unrivaled. Company representative, Michael Ng, tells me that CyanthOx is 9 times stronger than grape seed extract, which I’ve taken daily for years, and almost 2 times more powerful than pine bark extract. It’s ORAC (antioxidant) value is the highest ever measured in superfoods. That translates into health benefits that support cellular regeneration, cardiometabolic health and a balanced inflammatory  response.

Sea Buckthorn berry has been shown to raise antioxidant levels (e.g., SOD, GSH-Px; reduced MDA) in human clinical trials. Antioxidants neutralize damaging free radicals that make us age. CyanthOx® stimulates stem cells in humans by nearly 40%, which helps with tissue repair, and supports healthy aging. It’s also clinically proven to boost immune defenses, which combat colds, flu, cancer and other inflammatory disorders.

This potent antioxidant product offers a new, natural, non-antibiotic remedy for urinary tract infection (UTI). PAC antioxidants keep slimy germs from attaching to the urinary tract. Sea buckthorn berry has been shown clinically to help reduce the risk and duration of UTIs. That’s important to me because I’m prone to such infections.

Skin and eye health benefits have also been reported from sea buckthorn seed extracts, including collagen generation, skin glow, protection from solar damage, stress & environmental toxins.  Heart health was also improved, to include cholesterol quality, lowering triglycerides and blood sugar levels. Gut health is also supported, preventing ulcer occurrence and promoting its recovery.

Incorporating CyanthOx into my regimen was all about dissolving the powder in different liquids. It doesn’t take much, but even a little doesn’t taste great. (I should invest in a capsule maker.) Eventually, I put it in red wine and green tea to make them more tannic, and even more healthful. I came to enjoy it, but thank goodness these extracts come in capsule form.

For someone, who already takes 20-plus other supplements/extracts daily, it’s hard to discern the value of any new regimen. Experimentation with this product was not scientific by any means and was confounded by a host of other projects of mine. At baseline, I felt well, despite a few minor health issues I was hoping to address. So I started taking CyanthOx at ~250 mg daily for roughly 3 months. 

With all these possible benefits, I was eager to get on with this trial. At age 70, most people are dealing with an assortment of bumps and bruises, or worse. Almost half of the North American population is taking 5 or more drugs by the time they are 70, the most common being lipid-lowering, anti-diabetic, beta-blocking, analgesic, and proton pump-inhibiting drugs. I don’t take any of these drugs, and my diet is cutting edge, so I’m doing rather well in comparison to most my age. I have no circulatory or metabolic issues, like those which cause diabetes, or subjects people to severe Covid. However, I’ve got chronic tendinitis in my thumb from gardening, a pain in my right hip, dry skin at the extremities, bursitis in my neck/shoulder area from a car accident, and occasional inflammation in a joint or two, from meniscus tears and sprained-ankle injuries as a younger man.  

Since it increases collagen deposition, I thought it might help heal some of my nagging injuries and improve my skin. Alas, I’m afraid there’s no helping my thumb, but I had no inflammatory joint issues, or other pains, for the three months I was on CyanthOX. My energy levels were also good. I felt more alive, alert, outgoing, and less inclined to sadness during this experiment, and that’s saying a lot during this Covid pandemic. I also felt more in the spirit during the holidays, which is hard for me to do. But my dry skin remained.

The most striking difference was in my productivity. After starting CyanthOX (250 mg/day), I published five blogposts in three months, including this one. In contrast, just one other blogpost was published the entire year. CyanthOX woke me up in substantial ways.

I’m not sure about my cholesterol and blood chemistry, but they were already in the normal range. My blood pressure is fine. I had no gut issues, or headaches, or trouble sleeping, or other obvious problems during my trial with CyanthOX, but I really don’t have those any way. This extract would likely do even more good for someone with multiple issues. But I went up a few notches in aliveness and spirit. We’ll see if they wane, now that I’m no longer taking the extract. So far, so good.

Nutritional science is creating powerful potions from food extracts in our quest to live long and healthy lives. New technologies that enhance the impact of healthy plants may prove useful in protecting and enhancing our well-being as we age. In this regard, sea buckthorn antioxidants may be up there with the best of them.

Puredia. 2021. CyanthOx ™ | Strongest Plant-based Antioxidant — Puredia. [online] Available at: https://www.puredia.com/product/cyanthox.

Superfoodly. 2021. ORAC Values: Antioxidant Values of Foods & Beverages – Superfoodly. [online] Available at: https://www.superfoodly.com/orac-values/.

Larmo P, Alin J, Salminen E, Kallio H, Tahvonen R., 2007. Effects of sea buckthorn berries on infections and inflammation: a double-blind, randomized, placebo-controlled trial. Eur J Clin Nutr [online] 62(9), 1123-30. Available at: https://www.nature.com/articles/1602831.

Zielińska A, Nowak I. Abundance of active ingredients in sea- buckthorn oil. Lipids in Health and Disease (2017) 16:95 

Xiao-fei Guo, et al. Effect of sea buckthorn (Hippophae rhamnoides L.) on blood lipid profiles: A systematic review and meta-analysis from 11 independent randomized controlled trials. Trends Food Sci Technol 2017; 61:1–10.

NCHS Data Brief No. 347, August 2019. Prescription Drug Use Among Adults Aged 40–79 in the United States and Canada. https://www.cdc.gov/nchs/products/databriefs/db347.htm

2 thoughts on “Sea Buckthorn: The Next Generation of Antioxidants

  1. Hello again Dr Willip … what’s your take on melatonin as a Mitochondrial anti oxidant and stress calmer? Then the idea and use of high dose melatonin, like 100mg and up? It has no known lethal dose and is found in most all living things. All this is from Dr Russell Reiters long time melatonin research.

    How much closer are your BT to being used on people?

    Thanks again


    Gadoliniumtoxicity.com Floxiehope.com

    Sent from my iPhone


    • I’m just learning about the many aspects of melatonin. My immediate response was to get out in the sun and expose more skin, even in the cold. Interestingly, I slept through the night last night, which I don’t do very often. I know nothing about taking high doses of melatonin. It’s expensive enough at low doses.

      The BTs are moving along. The company developing them made some good strides last year, and garnered some needed funding to perform clinical trials this year. Those human trials make all the difference, if they’re positive. And they will be, from what I know about this drug. They’re looking for more funding, so now’s the time to invest while the share price is low.

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